Steroid-induced osteoporosis (SIOP) is osteoporosis arising due to use of glucocorticoids (steroid hormones) - analogous to Cushing's syndrome and involving mainly the axial skeleton. The synthetic glucocorticoid prescription drug prednisone is a main candidate after prolonged intake.
Mechanisms of SIOP include:
- Direct inhibition of osteoblast function
- Direct enhancement of bone resorption
- Inhibition of gastrointestinal calcium absorption
- Increased urine calcium loss
- Inhibition of sex steroids
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